Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo

Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (Sec23a and Sec23b). In humans, SEC23B deficiency results...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Khoriaty, Rami, Hesketh, Geoffrey G., Bernard, Amélie, Weyand, Angela C., Mellacheruvu, Dattatreya, Zhu, Guojing, Hoenerhoff, Mark J., McGee, Beth, Everett, Lesley, Adams, Elizabeth J., Zhang, Bin, Saunders, Thomas L., Nesvizhskii, Alexey I., Klionsky, Daniel J., Shavit, Jordan A., Gingras, Anne-Claude, Ginsburg, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099849/
https://ncbi.nlm.nih.gov/pubmed/30065114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805784115
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