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Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo
Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (Sec23a and Sec23b). In humans, SEC23B deficiency results...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099849/ https://ncbi.nlm.nih.gov/pubmed/30065114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805784115 |
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