Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo

Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (Sec23a and Sec23b). In humans, SEC23B deficiency results...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Khoriaty, Rami, Hesketh, Geoffrey G., Bernard, Amélie, Weyand, Angela C., Mellacheruvu, Dattatreya, Zhu, Guojing, Hoenerhoff, Mark J., McGee, Beth, Everett, Lesley, Adams, Elizabeth J., Zhang, Bin, Saunders, Thomas L., Nesvizhskii, Alexey I., Klionsky, Daniel J., Shavit, Jordan A., Gingras, Anne-Claude, Ginsburg, David
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099849/
https://ncbi.nlm.nih.gov/pubmed/30065114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805784115
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