ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T cell alloimmunity

T cell–mediated responses are dependent on their secretion of key effector molecules. However, the critical molecular determinants of the secretion of these proteins are largely undefined. Here, we demonstrate that T cell activation increases trafficking via the ER-to-Golgi pathway. To study the fun...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kim, Stephanie, Khoriaty, Rami, Li, Lu, McClune, Madison, Kalfa, Theodosia A., Wu, Julia, Peltier, Daniel, Fujiwara, Hideaki, Sun, Yaping, Oravecz-Wilson, Katherine, King, Richard A., Ginsburg, David, Reddy, Pavan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810489/
https://ncbi.nlm.nih.gov/pubmed/33463537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136574
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