Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e., fulvestrant, raloxifene, and tamoxifen) are weak provira...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Das, Biswajit, Dobrowolski, Curtis, Luttge, Benjamin, Valadkhan, Saba, Chomont, Nicolas, Johnston, Rowena, Bacchetti, Peter, Hoh, Rebecca, Gandhi, Monica, Deeks, Steven G., Scully, Eileen, Karn, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099847/
https://ncbi.nlm.nih.gov/pubmed/30061382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803468115
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