New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro

P-glycoprotein (Pgp) determines resistance to a broad spectrum of drugs used against glioblastoma multiforme (GB). Indeed, Pgp is highly expressed in GB stem cells and in the brain-blood barrier (BBB), the peculiar endothelium surrounding the brain. Inhibiting Pgp activity in the BBB and GB is still...

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Veröffentlicht in:Molecules
Hauptverfasser: Salaroglio, Iris Chiara, Gazzano, Elena, Kopecka, Joanna, Chegaev, Konstantin, Costamagna, Costanzo, Fruttero, Roberta, Guglielmo, Stefano, Riganti, Chiara
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099747/
https://ncbi.nlm.nih.gov/pubmed/29890725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23061401
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