Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance

[Image: see text] Nitric oxide (NO) release from a suitable NO photodonor (NOP) can be fine-tuned by visible light stimuli at doses that are not toxic to cells but that inhibit several efflux pumps; these are mainly responsible for the multidrug resistance of the anticancer agent doxorubicin (DOX)....

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Udgivet i:ACS Med Chem Lett
Main Authors: Chegaev, Konstantin, Fraix, Aurore, Gazzano, Elena, Abd-Ellatef, Gamal Eldein F., Blangetti, Marco, Rolando, Barbara, Conoci, Sabrina, Riganti, Chiara, Fruttero, Roberta, Gasco, Alberto, Sortino, Salvatore
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346994/
https://ncbi.nlm.nih.gov/pubmed/28337331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00016
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