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New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

P-glycoprotein (P-gp, MDR1) is a membrane transporter expressed in several regions of our body. It plays a crucial defense role as it mediates the efflux of hundreds of potentially toxic substances. However, P-gp is one of the main causes of failure in cancer chemotherapy, as a number of chemotherap...

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Detaylı Bibliyografya
Yayımlandı:Medchemcomm
Asıl Yazarlar: Contino, Marialessandra, Guglielmo, Stefano, Perrone, Maria Grazia, Giampietro, Roberta, Rolando, Barbara, Carrieri, Antonio, Zaccaria, Daniele, Chegaev, Konstantin, Borio, Vanessa, Riganti, Chiara, Zabielska-Koczywąs, Katarzyna, Colabufo, Nicola A., Fruttero, Roberta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071824/
https://ncbi.nlm.nih.gov/pubmed/30108975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00075a
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