6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

Aiming to deepen the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold linked to different methoxy-substituted aryl moieties w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Enzyme Inhib Med Chem
Egile Nagusiak: Braconi, Laura, Bartolucci, Gianluca, Contino, Marialessandra, Chiaramonte, Niccolò, Giampietro, Roberta, Manetti, Dina, Perrone, Maria Grazia, Romanelli, Maria Novella, Colabufo, Nicola Antonio, Riganti, Chiara, Dei, Silvia, Teodori, Elisabetta
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2020
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178819/
https://ncbi.nlm.nih.gov/pubmed/32253945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1747449
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