Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †

A new series of N,N-bis(alkanol)amine aryl diesters was synthesized and studied as dual P-glycoprotein (P-gp) and carbonic anhydrase XII inhibitors (CA XII). These hybrids should be able to synergistically overcome P-gp mediated multidrug resistance (MDR) in cancer cells. It was reported that the ef...

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Publicado no:Molecules
Main Authors: Teodori, Elisabetta, Braconi, Laura, Bua, Silvia, Lapucci, Andrea, Bartolucci, Gianluca, Manetti, Dina, Romanelli, Maria Novella, Dei, Silvia, Supuran, Claudiu T., Coronnello, Marcella
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181201/
https://ncbi.nlm.nih.gov/pubmed/32290281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071748
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