Impact of patatin‐like phospholipase domain containing 3 rs738409 G/G genotype on hepatic decompensation and mortality in patients with portal hypertension

BACKGROUND: The rs738409 C>G p.I148M variant in the patatin‐like phospholipase domain containing 3 (PNPLA3)‐gene promotes triglyceride accumulation in hepatocytes and hepatic stellate cell activation and has previously been linked to hepatic steatosis/liver fibrosis. AIM: To investigate its impac...

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Pubblicato in:Aliment Pharmacol Ther
Autori principali: Mandorfer, M., Scheiner, B., Stättermayer, A. F., Schwabl, P., Paternostro, R., Bauer, D., Schaefer, B., Zoller, H., Peck‐Radosavljevic, M., Trauner, M., Reiberger, T., Ferenci, P., Ferlitsch, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Hepatic Decompensation in Portal Hypertension
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099386/
https://ncbi.nlm.nih.gov/pubmed/29956823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.14856
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