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Synergistic Effect of Simvastatin and Romidepsin on Gamma-globin Gene Induction

OBJECTIVE: Hemoglobinopathies such as beta-thalassemia and sickle cell disease (SCD) are inherited disorders that are caused by mutations in beta-globin chain. Gamma-globin gene reactivation can ameliorate clinical manifestations of beta- thalassemia and SCD. Drugs that induce fetal hemoglobin (HbF)...

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Bibliografske podrobnosti
izdano v:Cell J
Main Authors: Habibi, Hussain, Atashi, Amir, Abroun, Saeid, Noruzinia, Mehrdad
Format: Artigo
Jezik:Inglês
Izdano: Royan Institute 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099151/
https://ncbi.nlm.nih.gov/pubmed/30124006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22074/cellj.2019.5589
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