Synergistic Effect of Simvastatin and Romidepsin on Gamma-globin Gene Induction

OBJECTIVE: Hemoglobinopathies such as beta-thalassemia and sickle cell disease (SCD) are inherited disorders that are caused by mutations in beta-globin chain. Gamma-globin gene reactivation can ameliorate clinical manifestations of beta- thalassemia and SCD. Drugs that induce fetal hemoglobin (HbF)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell J
Prif Awduron: Habibi, Hussain, Atashi, Amir, Abroun, Saeid, Noruzinia, Mehrdad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royan Institute 2019
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099151/
https://ncbi.nlm.nih.gov/pubmed/30124006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22074/cellj.2019.5589
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