DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin complex 1 (mTORC1) plays a causal r...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Chen, Hanqing, Shen, Feng, Sherban, Alex, Nocon, Allison, Li, Yu, Wang, Hua, Xu, Ming-Jiang, Rui, Xianliang, Han, Jinyan, Jiang, Bingbing, Lee, Donghwan, Li, Na, Keyhani-Nejad, Farnaz, Fan, Jian-gao, Liu, Feng, Kamat, Amrita, Musi, Nicolas, Guarente, Leonard, Pacher, Pal, Gao, Bin, Zang, Mengwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097912/
https://ncbi.nlm.nih.gov/pubmed/29457836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29849
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