Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes

De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity, leading to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Genetic lipogenic programs have been extensively investigated, but epige...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Liu, Yan, Lin, Haiyan, Jiang, Lin, Shang, Qingsen, Yin, Lei, Lin, Jiandie D., Wu, Wen-Shu, Rui, Liangyou
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260003/
https://ncbi.nlm.nih.gov/pubmed/32365055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128073
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