DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin complex 1 (mTORC1) plays a causal r...

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Udgivet i:Hepatology
Main Authors: Chen, Hanqing, Shen, Feng, Sherban, Alex, Nocon, Allison, Li, Yu, Wang, Hua, Xu, Ming-Jiang, Rui, Xianliang, Han, Jinyan, Jiang, Bingbing, Lee, Donghwan, Li, Na, Keyhani-Nejad, Farnaz, Fan, Jian-gao, Liu, Feng, Kamat, Amrita, Musi, Nicolas, Guarente, Leonard, Pacher, Pal, Gao, Bin, Zang, Mengwei
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097912/
https://ncbi.nlm.nih.gov/pubmed/29457836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29849
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