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Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls

Synthetic lethal interactions, in which the simultaneous loss-of-function of two genes produces a lethal phenotype, are being explored as a means to therapeutically exploit cancer-specific vulnerabilities and expand the scope of precision oncology. Currently, three FDA approved drugs work by targeti...

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Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Shen, John Paul, Ideker, Trey
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097899/
https://ncbi.nlm.nih.gov/pubmed/29932943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.06.026
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