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Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls
Synthetic lethal interactions, in which the simultaneous loss-of-function of two genes produces a lethal phenotype, are being explored as a means to therapeutically exploit cancer-specific vulnerabilities and expand the scope of precision oncology. Currently, three FDA approved drugs work by targeti...
Tallennettuna:
| Julkaisussa: | J Mol Biol |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097899/ https://ncbi.nlm.nih.gov/pubmed/29932943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.06.026 |
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