Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain

Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes of Hsp90 modulation. After the identification of novobiocin as a C-Hsp90 interacting ligand a diverse gamut of novologues emerged, from which KU-32 and KU-596 exhibited s...

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Vydáno v:Medchemcomm
Hlavní autoři: Kumar MV, Vasantha, Ebna Noor, Radwan, Davis, Rachel E., Zhang, Zheng, Sipavicius, Edvinas, Keramisanou, Dimitra, Blagg, Brian S. J., Gelis, Ioannis
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097425/
https://ncbi.nlm.nih.gov/pubmed/30151087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00151k
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