Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation

BACKGROUND: Inhibition of Hsp90 is desirable due to potential downregulation of oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C-terminal domain (CTD) inhibitors are a promising class because they do not induce a heat shock response. Here we present a new stru...

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Publicado en:Biochim Biophys Acta Gen Subj
Autores principales: Goode, Kourtney M., Petrov, Dino P., Vickman, Renee E., Crist, Scott A., Pascuzzi, Pete E., Ratliff, Tim L., Davisson, V. Jo, Hazbun, Tony R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453127/
https://ncbi.nlm.nih.gov/pubmed/28495207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.05.006
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