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A scaffold merging approach to Hsp90 C-terminal inhibition: synthesis and evaluation of a chimeric library
Inhibition of the Hsp90 C-terminus is an attractive therapeutic paradigm for the treatment of cancer, however the developmental space of C-terminal inhibitors is limited. It was hypothesized that the combination of two previously identified scaffolds into a single structure could provide a platform...
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| Udgivet i: | Medchemcomm |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437984/ https://ncbi.nlm.nih.gov/pubmed/28533894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00377j |
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