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Synthesis and biological evaluation of stilbene analogs as Hsp90 C-terminal inhibitors
The design, synthesis and biological evaluation of stilbene-based novobiocin analogs is reported. Replacement of the biaryl amide side chain with a triazole side chain produced compounds that exhibited good anti-proliferative activities. Hsp90 inhibition was observed when N-methyl piperidine was rep...
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| Publicado en: | ChemMedChem |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5892432/ https://ncbi.nlm.nih.gov/pubmed/29058824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700630 |
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