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Synthesis and biological evaluation of novobiocin core analogs as Hsp90 inhibitors
Development of Heat shock protein 90 (Hsp90) C-terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products novobiocin and coumermycin. Moreover, variations in both the sugar and amide moieties have been e...
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| Pubblicato in: | Chemistry |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4962924/ https://ncbi.nlm.nih.gov/pubmed/27037933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201504955 |
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