Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

BACKGROUND: Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncogene-induced senescence, a cellular state of irreversible proliferation arrest th...

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Udgivet i:Genome Biol
Main Authors: Han, Ruiqi, Li, Li, Ugalde, Alejandro Piñeiro, Tal, Arieh, Manber, Zohar, Barbera, Eric Pinto, Chiara, Veronica Della, Elkon, Ran, Agami, Reuven
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097335/
https://ncbi.nlm.nih.gov/pubmed/30119690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1494-1
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