A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

Estrogen receptor α (ERα) is an enhancer activating transcription factor, a key driver of breast cancer and a main target for cancer therapy. ERα-mediated gene regulation requires proper chromatin-conformation to facilitate interactions between ERα-bound enhancers and their target promoters. A major...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Korkmaz, Gozde, Manber, Zohar, Lopes, Rui, Prekovic, Stefan, Schuurman, Karianne, Kim, Yongsoo, Teunissen, Hans, Flach, Koen, de Wit, Elzo, Galli, Giorgio G, Zwart, Wilbert, Elkon, Ran, Agami, Reuven
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765117/
https://ncbi.nlm.nih.gov/pubmed/31372638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz675
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