Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression

Inactivation of all herpes simplex virus (HSV) immediate early (IE) genes to eliminate vector cytotoxicity results in rapid silencing of the viral genome, similar to the establishment of HSV latency. We recently reported that silencing of a nonviral reporter cassette could be overcome in nonneuronal...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Han, Fang, Miyagawa, Yoshitaka, Verlengia, Gianluca, Ingusci, Selene, Soukupova, Marie, Simonato, Michele, Glorioso, Joseph C., Cohen, Justus B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Gene Delivery
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096828/
https://ncbi.nlm.nih.gov/pubmed/29950408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00536-18
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