Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression

Inactivation of all herpes simplex virus (HSV) immediate early (IE) genes to eliminate vector cytotoxicity results in rapid silencing of the viral genome, similar to the establishment of HSV latency. We recently reported that silencing of a nonviral reporter cassette could be overcome in nonneuronal...

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Vydáno v:J Virol
Hlavní autoři: Han, Fang, Miyagawa, Yoshitaka, Verlengia, Gianluca, Ingusci, Selene, Soukupova, Marie, Simonato, Michele, Glorioso, Joseph C., Cohen, Justus B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Gene Delivery
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096828/
https://ncbi.nlm.nih.gov/pubmed/29950408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00536-18
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