Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression

Inactivation of all herpes simplex virus (HSV) immediate early (IE) genes to eliminate vector cytotoxicity results in rapid silencing of the viral genome, similar to the establishment of HSV latency. We recently reported that silencing of a nonviral reporter cassette could be overcome in nonneuronal...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Han, Fang, Miyagawa, Yoshitaka, Verlengia, Gianluca, Ingusci, Selene, Soukupova, Marie, Simonato, Michele, Glorioso, Joseph C., Cohen, Justus B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096828/
https://ncbi.nlm.nih.gov/pubmed/29950408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00536-18
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