Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity

The design of highly defective herpes simplex virus (HSV) vectors for transgene expression in nonneuronal cells in the absence of toxic viral-gene activity has been elusive. Here, we report that elements of the latency locus protect a nonviral promoter against silencing in primary human cells in the...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Miyagawa, Yoshitaka, Marino, Pietro, Verlengia, Gianluca, Uchida, Hiroaki, Goins, William F., Yokota, Shinichiro, Geller, David A., Yoshida, Osamu, Mester, Joseph, Cohen, Justus B., Glorioso, Joseph C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386379/
https://ncbi.nlm.nih.gov/pubmed/25775541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423556112
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