Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity

The design of highly defective herpes simplex virus (HSV) vectors for transgene expression in nonneuronal cells in the absence of toxic viral-gene activity has been elusive. Here, we report that elements of the latency locus protect a nonviral promoter against silencing in primary human cells in the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Miyagawa, Yoshitaka, Marino, Pietro, Verlengia, Gianluca, Uchida, Hiroaki, Goins, William F., Yokota, Shinichiro, Geller, David A., Yoshida, Osamu, Mester, Joseph, Cohen, Justus B., Glorioso, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386379/
https://ncbi.nlm.nih.gov/pubmed/25775541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423556112
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