Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

The ability of herpes simplex virus (HSV) to establish lifelong latency in neurons suggests that HSV-derived vectors hold promise for gene delivery to the nervous system. However, vector toxicity and transgene silencing have created significant barriers to vector applications to the brain. Recently,...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Miyagawa, Yoshitaka, Verlengia, Gianluca, Reinhart, Bonnie, Han, Fang, Uchida, Hiroaki, Zucchini, Silvia, Goins, William F., Simonato, Michele, Cohen, Justus B., Glorioso, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493822/
https://ncbi.nlm.nih.gov/pubmed/28702475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.06.001
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