Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV

Glioblastoma multiforme (GBM) is an aggressive brain cancer for which there is no effective treatment. Oncolytic HSV vectors (oHSVs) are attenuated lytic viruses that have shown promise in the treatment of human GBM models in animals, but their efficacy in early phase patient trials has been limited...

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Publicado en:Mol Ther
Autores principales: Mazzacurati, Lucia, Marzulli, Marco, Reinhart, Bonnie, Miyagawa, Yoshitaka, Uchida, Hiroaki, Goins, William F, Li, Aofei, Kaur, Balveen, Caligiuri, Michael, Cripe, Timothy, Chiocca, Nino, Amankulor, Nduka, Cohen, Justus B, Glorioso, Joseph C, Grandi, Paola
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426800/
https://ncbi.nlm.nih.gov/pubmed/25200130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.177
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