Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV

Glioblastoma multiforme (GBM) is an aggressive brain cancer for which there is no effective treatment. Oncolytic HSV vectors (oHSVs) are attenuated lytic viruses that have shown promise in the treatment of human GBM models in animals, but their efficacy in early phase patient trials has been limited...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Mazzacurati, Lucia, Marzulli, Marco, Reinhart, Bonnie, Miyagawa, Yoshitaka, Uchida, Hiroaki, Goins, William F, Li, Aofei, Kaur, Balveen, Caligiuri, Michael, Cripe, Timothy, Chiocca, Nino, Amankulor, Nduka, Cohen, Justus B, Glorioso, Joseph C, Grandi, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426800/
https://ncbi.nlm.nih.gov/pubmed/25200130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.177
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