Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV

Glioblastoma multiforme (GBM) is an aggressive brain cancer for which there is no effective treatment. Oncolytic HSV vectors (oHSVs) are attenuated lytic viruses that have shown promise in the treatment of human GBM models in animals, but their efficacy in early phase patient trials has been limited...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Mazzacurati, Lucia, Marzulli, Marco, Reinhart, Bonnie, Miyagawa, Yoshitaka, Uchida, Hiroaki, Goins, William F, Li, Aofei, Kaur, Balveen, Caligiuri, Michael, Cripe, Timothy, Chiocca, Nino, Amankulor, Nduka, Cohen, Justus B, Glorioso, Joseph C, Grandi, Paola
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426800/
https://ncbi.nlm.nih.gov/pubmed/25200130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.177
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