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Acidic pH Mediates Changes in Antigenic and Oligomeric Conformation of Herpes Simplex Virus gB and Is a Determinant of Cell-Specific Entry

Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low-pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When n...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Weed, Darin J., Dollery, Stephen J., Komala Sari, Tri, Nicola, Anthony V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096812/
https://ncbi.nlm.nih.gov/pubmed/29925660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01034-18
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