A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence

Zoonotic highly pathogenic avian influenza viruses (HPAIV) have raised serious public health concerns of a novel pandemic. These strains emerge from low-pathogenic precursors by the acquisition of a polybasic hemagglutinin (HA) cleavage site, the prime virulence determinant. However, required coadap...

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Xehetasun bibliografikoak
Argitaratua izan da:J Virol
Egile Nagusiak: Wessels, Ute, Abdelwhab, Elsayed M., Veits, Jutta, Hoffmann, Donata, Mamerow, Svenja, Stech, Olga, Hellert, Jan, Beer, Martin, Mettenleiter, Thomas C., Stech, Jürgen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2018
Gaiak:
Pathogenesis and Immunity
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096801/
https://ncbi.nlm.nih.gov/pubmed/29899102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00778-18
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