A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence

Zoonotic highly pathogenic avian influenza viruses (HPAIV) have raised serious public health concerns of a novel pandemic. These strains emerge from low-pathogenic precursors by the acquisition of a polybasic hemagglutinin (HA) cleavage site, the prime virulence determinant. However, required coadap...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wessels, Ute, Abdelwhab, Elsayed M., Veits, Jutta, Hoffmann, Donata, Mamerow, Svenja, Stech, Olga, Hellert, Jan, Beer, Martin, Mettenleiter, Thomas C., Stech, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096801/
https://ncbi.nlm.nih.gov/pubmed/29899102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00778-18
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