A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence

Zoonotic highly pathogenic avian influenza viruses (HPAIV) have raised serious public health concerns of a novel pandemic. These strains emerge from low-pathogenic precursors by the acquisition of a polybasic hemagglutinin (HA) cleavage site, the prime virulence determinant. However, required coadap...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Wessels, Ute, Abdelwhab, Elsayed M., Veits, Jutta, Hoffmann, Donata, Mamerow, Svenja, Stech, Olga, Hellert, Jan, Beer, Martin, Mettenleiter, Thomas C., Stech, Jürgen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2018
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096801/
https://ncbi.nlm.nih.gov/pubmed/29899102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00778-18
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