Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

BACKGROUND: Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies r...

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Bibliografiske detaljer
Udgivet i:EJNMMI Res
Main Authors: Amor, Dorra, Goutal, Sébastien, Marie, Solène, Caillé, Fabien, Bauer, Martin, Langer, Oliver, Auvity, Sylvain, Tournier, Nicolas
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095934/
https://ncbi.nlm.nih.gov/pubmed/30116910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-018-0434-0
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