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Diphenhydramine as a selective probe to study H(+)-antiporter function at the blood–brain barrier: Application to [(11)C]diphenhydramine positron emission tomography imaging
Diphenhydramine, a sedative histamine H(1)-receptor (H(1)R) antagonist, was evaluated as a probe to measure drug/H(+)-antiporter function at the blood–brain barrier. In situ brain perfusion experiments in mice and rats showed that diphenhydramine transport at the blood–brain barrier was saturable, f...
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| Publicat a: | J Cereb Blood Flow Metab |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
SAGE Publications
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464711/ https://ncbi.nlm.nih.gov/pubmed/27488910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16662042 |
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