A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

Oncolytic herpes simplex viruses (oHSVs) showed efficacy in clinical trials and practice. Most of them gain cancer-specificity from deletions/mutations in genes that counteract the host response, and grow selectively in cancer cells defective in anti-viral response. Because of the deletions/mutation...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Leoni, Valerio, Vannini, Andrea, Gatta, Valentina, Rambaldi, Julie, Sanapo, Mara, Barboni, Catia, Zaghini, Anna, Nanni, Patrizia, Lollini, Pier-Luigi, Casiraghi, Costanza, Campadelli-Fiume, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095629/
https://ncbi.nlm.nih.gov/pubmed/30080893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007209
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