AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer

Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as “telomere syndromes”, which are provoked by extrem...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Muñoz-Lorente, Miguel A., Martínez, Paula, Tejera, Águeda, Whittemore, Kurt, Moisés-Silva, Ana Carolina, Bosch, Fàtima, Blasco, Maria A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095492/
https://ncbi.nlm.nih.gov/pubmed/30114189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007562
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