Pten Inactivation Accelerates Oncogenic K-ras-Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Alth...

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Main Authors: Iwanaga, Kentaro, Yang, Yanan, Raso, Maria Gabriela, Ma, Lijiang, Hanna, Amy E., Thilaganathan, Nishan, Moghaddam, Seyed, Evans, Christopher M., Li, Huaiguang, Cai, Wei-Wen, Sato, Mitsuo, Minna, John D., Wu, Hong, Creighton, Chad J., Demayo, Francesco J., Wistuba, Ignacio I., Kurie, Jonathan M.
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750029/
https://ncbi.nlm.nih.gov/pubmed/18281487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-3117
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