Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

BACKGROUND: Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is modifiable, these observations have substantial clinical and public h...

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Bibliografske podrobnosti
izdano v:BMC Med
Main Authors: He, Yazhou, Timofeeva, Maria, Farrington, Susan M., Vaughan-Shaw, Peter, Svinti, Victoria, Walker, Marion, Zgaga, Lina, Meng, Xiangrui, Li, Xue, Spiliopoulou, Athina, Jiang, Xia, Hyppönen, Elina, Kraft, Peter, Kiel, Douglas P., Hayward, Caroline, Campbell, Archie, Porteous, David, Vucic, Katarina, Kirac, Iva, Filipovic, Masa, Harris, Sarah E., Deary, Ian J., Houlston, Richard, Tomlinson, Ian P., Campbell, Harry, Theodoratou, Evropi, Dunlop, Malcolm G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090711/
https://ncbi.nlm.nih.gov/pubmed/30103784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-018-1119-2
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