Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

BACKGROUND: Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is modifiable, these observations have substantial clinical and public h...

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Pubblicato in:BMC Med
Autori principali: He, Yazhou, Timofeeva, Maria, Farrington, Susan M., Vaughan-Shaw, Peter, Svinti, Victoria, Walker, Marion, Zgaga, Lina, Meng, Xiangrui, Li, Xue, Spiliopoulou, Athina, Jiang, Xia, Hyppönen, Elina, Kraft, Peter, Kiel, Douglas P., Hayward, Caroline, Campbell, Archie, Porteous, David, Vucic, Katarina, Kirac, Iva, Filipovic, Masa, Harris, Sarah E., Deary, Ian J., Houlston, Richard, Tomlinson, Ian P., Campbell, Harry, Theodoratou, Evropi, Dunlop, Malcolm G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090711/
https://ncbi.nlm.nih.gov/pubmed/30103784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-018-1119-2
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