Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

DJ-1 plays an important role in antioxidant defenses, and a reactive cysteine at position 106 (Cys106) of DJ-1, a critical residue of its biological function, is oxidized under oxidative stress. DJ-1 oxidation has been reported in patients with Parkinson’s disease (PD), but the relationship between...

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Udgivet i:Sci Rep
Main Authors: Mita, Yuichiro, Kataoka, Yuto, Saito, Yoshiro, Kashi, Takuma, Hayashi, Kojiro, Iwasaki, Asa, Imanishi, Takanori, Miyasaka, Tomohiro, Noguchi, Noriko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089991/
https://ncbi.nlm.nih.gov/pubmed/30104666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30561-z
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