Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients

Parkinson’s disease (PD) is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1, the product of the causative gene of a familial form of PD, plays a significant role in anti-oxidative defence to protect cells from oxidative...

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Pubblicato in:Sci Rep
Autori principali: Saito, Yoshiro, Akazawa-Ogawa, Yoko, Matsumura, Akihiro, Saigoh, Kazumasa, Itoh, Sayoko, Sutou, Kenta, Kobayashi, Mayuka, Mita, Yuichiro, Shichiri, Mototada, Hisahara, Shin, Hara, Yasuo, Fujimura, Harutoshi, Takamatsu, Hiroyuki, Hagihara, Yoshihisa, Yoshida, Yasukazu, Hamakubo, Takao, Kusunoki, Susumu, Shimohama, Shun, Noguchi, Noriko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965792/
https://ncbi.nlm.nih.gov/pubmed/27470541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30793
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