Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione

DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported to undergo preferential oxidation of the cysteine residue at position 106 (Cys-106) under oxidative stress; however, details of the molecular mechanisms are not well known. In the present study, mechanism...

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Bibliografiske detaljer
Main Authors: Miyama, Akiko, Saito, Yoshiro, Yamanaka, Kazunori, Hayashi, Kojiro, Hamakubo, Takao, Noguchi, Noriko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221727/
https://ncbi.nlm.nih.gov/pubmed/22132160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027883
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