Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo

Overexpressing of ATP-binding cassette (ABC) transporters is the essential cause of multidrug resistance (MDR), which is a significant hurdle to the success of chemotherapy in many cancers. Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR. Olmutinib...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Pharm Sin B
Auteurs principaux: Zhang, Zhiqiang, Guo, Xiaoran, To, Kenneth K.W., Chen, Zhen, Fang, Xiaona, Luo, Min, Ma, Chunling, Xu, Jianhua, Yan, Shirong, Fu, Liwu
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089862/
https://ncbi.nlm.nih.gov/pubmed/30109181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.06.002
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