Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1

ABCB1-mediated multidrug resistance (MDR) remains a major obstacle to successful chemotherapy in ovarian cancer. Herein, afatinib at nontoxic concentrations significantly reversed ABCB1-mediated MDR in ovarian cancer cells in vitro (p < 0.05). Combining paclitaxel and afatinib caused tumor regres...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Wang, Sheng-qi, Liu, Shi-ting, Zhao, Bo-xin, Yang, Fu-heng, Wang, Ya-tian, Liang, Qian-ying, Sun, Ya-bin, Liu, Yuan, Song, Zhi-hua, Cai, Yun, Li, Guo-feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694892/
https://ncbi.nlm.nih.gov/pubmed/26317651
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