Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo

Multidrug resistance (MDR) to chemotherapeutic drugs is a formidable barrier to the success of cancer chemotherapy. Expressions of ATP-binding cassette (ABC) transporters contribute to clinical MDR phenotype. In this study, we found that afatinib, a small molecule tyrosine kinase inhibitor (TKI) tar...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Xiao-kun, Kin Wah To, Kenneth, Huang, Li-yan, Xu, Jing-hong, Yang, Ke, Wang, Fang, Huang, Zhen-cong, Ye, Sheng, Fu, Li-wu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322967/
https://ncbi.nlm.nih.gov/pubmed/25436978
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