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Physiologically‐based pharmacokinetic model of vaginally administered dapivirine ring and film formulations

AIMS: A physiologically‐based pharmacokinetic (PBPK) model of the vaginal space was developed with the aim of predicting concentrations in the vaginal and cervical space. These predictions can be used to optimize the probability of success of vaginally administered dapivirine (DPV) for HIV preventio...

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Publicat a:Br J Clin Pharmacol
Autors principals: Kay, Katherine, Shah, Dhaval K., Rohan, Lisa, Bies, Robert
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089833/
https://ncbi.nlm.nih.gov/pubmed/29714824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13625
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