A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film

BACKGROUND: Films may deliver antiretroviral drugs efficiently to mucosal tissues. In this first in-human trial of a vaginal film for delivering the non-nucleoside reverse transcriptase inhibitor dapivirine, safety, pharmacokinetics, and pharmacodynamics of film and gel formulations were compared to...

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Pubblicato in:J Acquir Immune Defic Syndr
Autori principali: Bunge, Authors: Katherine E., Dezzutti, Charlene S., Rohan, Lisa C., Hendrix, Craig W., Marzinke, Mark A., Richardson-Harman, Nicola, Moncla, Bernard J., Devlin, Brid, Meyn, Leslie A., M.L.Spiegel, Hans, Hillier, Sharon L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040830/
https://ncbi.nlm.nih.gov/pubmed/26565716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000897
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