Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: a Double-Blind Randomized Trial

BACKGROUND: Variable adherence limits effectiveness of daily oral and intravaginal tenofovir-containing pre-exposure prophylaxis. Monthly vaginal antiretroviral rings are one approach to improve adherence and drug delivery. METHODS: MTN-013/IPM 026, a multi-site, double-blind, randomized, placebo-co...

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Gepubliceerd in:J Acquir Immune Defic Syndr
Hoofdauteurs: Chen, Beatrice A., Panther, Lori, Marzinke, Mark A., Hendrix, Craig W., Hoesley, Craig J., van der Straten, Ariane, Husnik, Marla J., Soto-Torres, Lydia, Nel, Annalene, Johnson, Sherri, Richardson-Harman, Nicola, Rabe, Lorna K., Dezzutti, Charlene S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607587/
https://ncbi.nlm.nih.gov/pubmed/26034880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000702
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