Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial

BACKGROUND: The ex vivo challenge assay is a bio-indicator of drug efficacy and was utilized in this randomized, placebo controlled trial as one of the exploratory endpoints. Fresh and cryopreserved tissues were evaluated for human immunodeficiency virus (HIV) infection and pharmacokinetic (PK)/phar...

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發表在:Medicine (Baltimore)
Main Authors: Dezzutti, Charlene S., Richardson-Harman, Nicola, Rohan, Lisa C., Marzinke, Mark A., Hoesley, Craig J., Panther, Lori, Johnson, Sherri, Nuttall, Jeremy P., Nel, Annalene, Chen, Beatrice A.
格式: Artigo
語言:Inglês
出版: Wolters Kluwer Health 2016
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4850
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956805/
https://ncbi.nlm.nih.gov/pubmed/27428211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000004174
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