Pharmacodynamic activity of Dapivirine and Maraviroc single entity and combination topical gels for HIV-1 prevention

PURPOSE: Dapivirine (DPV), a non-nucleoside reverse transcriptase inhibitor, and maraviroc (MVC), a CCR5 antagonist, were formulated into aqueous gels designed to prevent mucosal HIV transmission. METHODS: 0.05% DPV, 0.1% MVC, 0.05% DPV/0.1% MVC and placebo gels were evaluated for pH, viscosity, osm...

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Pubblicato in:Pharm Res
Autori principali: Dezzutti, Charlene S., Yandura, Sarah, Wang, Lin, Moncla, Bernard, Teeple, Elizabeth A., Devlin, Brid, Nuttall, Jeremy, Brown, Elizabeth R., Rohan, Lisa C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600024/
https://ncbi.nlm.nih.gov/pubmed/26078001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1738-7
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